Scientific Name: Rattus norvegicus
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Euarchontoglires-> Glires-> Rodentia-> Myomorpha-> Muroidea-> Muridae-> Murinae
Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_1001 | 2019.12 | 10X Genomics | Lung | Normal | 5029 | Link |
| Vthunter_1002 | 2019.12 | 10X Genomics | Lung | Normal | 5924 | Link |
| Vthunter_1009 | 2017.11 | Fluidigm C1 | UrogenitalSinus | Normal | 114 | Link |
| Vthunter_110073 | 2019.12 | MARS-seq | TotalBrain | Normal | 2304 | Link |
Featureplot of receptors
Expression: Ubiquitous expression in colon (RPKM 44.7), placenta (RPKM 40.9) and 24 other tissues?
